Fatal multiorgan failure in baclofen overdose: An autopsy case report

[Non-fatal paliperidone overdose: a case report].

Paliperidone, a novel serotonin and dopamine antagonist, is one of the newest atypical antipsychotics on the market. It is an orally administered drug that is indicated for the treatment of schizophrenia, and is considered to be safe and well tolerated. A 37-year-old female with a long-standing history of schizophrenia had been taking paliperidone 12 mg d-1 for about 1.5 years. She overdosed on...

Non-Fatal Amlodipine and Insulin Overdose in an Elderly Person

Baclofen overdose.

A 57-year-old woman suffering from multiple sclerosis took an estimated 1500 mg of baclofen. She became deeply unconscious with generalized flaccid muscle paralysis and absent tendon reflexes. Toxicological analysis confirmed the presence of baclofen together with small amounts of paracetamol and glutethimide. Supportive therapy, including assisted ventilation for 3 days, led to complete recove...

Fatal Multiorgan Failure Associated with Disseminated Herpes Simplex Virus-1 Infection: A Case Report

Herpes simplex virus type 1 (HSV-1) infections cause typical dermal and mucosal lesions in children and adults. Also complications to the peripheral and central nervous system, pneumonia or hepatitis are well known. However, dissemination to viscera in adults is rare and predominantly observed in immunocompromised patients. Here we describe the case of a 70-year-old male admitted with macrohema...

Massive baclofen overdose.

A case is presented of a massive baclofen overdose with the highest blood baclofen concentrations currently reported. Interesting clinical features included profound hypotension, distributive shock and absent brainstem reflexes. Cerebral recovery was surprisingly slow but complete, and was then unexpectedly terminated by a sudden major splenic arterial haemorrhage followed by a severe haemorrha...